Case 508 · ICHD-3 8.1.1.2
8.1.1.2 Delayed NO donor-induced headache
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Male patient, 45 years old, with a history of hypertension and stable angina, on regular use of nitrate (isosorbide) for 3 months.
Report: Reports a holocranial, pulsatile headache of moderate to severe intensity, occurring 5 hours after nitrate administration and persisting for up to 12 hours. The pain is exacerbated by physical exertion and improves spontaneously. Denies associated photophobia, phonophobia, or nausea. Reports similar episodes on more than 3 occasions, always with a consistent temporal relationship with the use of the drug.
Physical/Neurological Examination: No abnormalities.
Investigation: Laboratory tests and neuroimaging (cranial CT) normal.
Report this case — e.g. suspected re-identification risk.