Case 534 · ICHD-3 8.1.6.1
8.1.6.1 Immediate histamine-induced headache
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: A 32-year-old male patient reports recurrent episodes of moderate, pulsatile bifrontal headache lasting 10 to 30 minutes, occurring immediately after the ingestion of histamine-rich foods (e.g., aged cheeses, red wine).
Examinations/Investigation:
Clinical history and headache diary confirm a temporal correlation with histamine ingestion.
Oral provocation test (under medical supervision) reproduces symptoms.
Imaging studies (cranial MRI) are normal, ruling out other causes.
Report this case — e.g. suspected re-identification risk.