Case 536 · ICHD-3 8.1.6.2

8.1.6.2 Delayed histamine-induced headache

Origin

Synthetic

Language

English — also available in German

Contributed by

Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)

Anamnesis

Identification: A 45-year-old male patient reports a history of headaches and has been experiencing recurrent episodes of bilateral, throbbing headache lasting 12 to 24 hours, starting 3 to 4 hours after consuming foods rich in histamine (e.g., aged cheeses, red wine). The pain is moderate to severe, associated with nausea and photophobia, without aura. Symptoms improve spontaneously.

Report this case — e.g. suspected re-identification risk.