Case 538 · ICHD-3 8.1.7.1

8.1.7.1 Immediate CGRP-induced headache

Origin

Synthetic

Language

English — also available in German

Contributed by

Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)

Anamnesis

Identification: Female patient, 45 years old, participating in a clinical study with calcitonin gene-related peptide (CGRP) for the investigation of cardiovascular therapies.

History:

Chief complaint: Mild to moderate, pulsatile, bilateral headache with sudden onset (in <1 hour) following intravenous infusion of CGRP.

Characteristics: Duration of 1 hour, associated with photophobia and nausea, without neurological deficit.

Background: No previous history of primary headaches (such as migraine or tension-type headache).

Complementary examinations: Brain MRI and MR angiography without abnormalities (performed to rule out other causes).

Report this case — e.g. suspected re-identification risk.