Case 540 · ICHD-3 8.1.7.2
8.1.7.2 Delayed CGRP-induced headache
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Female patient, 45 years old, with a history of chronic migraine, undergoing treatment with a CGRP receptor antagonist (erenumab) for 3 months.
Current History: Reports the onset of a holocranial headache, oppressive in nature and of moderate intensity, which began 5 days after the last administration of the CGRP antagonist. The headache persists for 72 hours, without typical migraine characteristics, and does not respond to common analgesics. There are no associated symptoms (nausea, photophobia, or phonophobia). The patient denies any prior history of headache with this pattern before using the medication.
Complementary Exams: Brain MRI without alterations.
Report this case — e.g. suspected re-identification risk.