Case 168 · ICHD-3 13.8
13.8 Tolosa–Hunt syndrome
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Female patient, 42 years old, with orbital pain and progressive ophthalmoplegia for 3 weeks.
History of Present Illness: Ocular Symptoms: Pain: Location: Retro-orbital and left frontal
Characteristic: Constant, "deep pressure" (7/10 VAS) Lancing exacerbations with eye movements No response to conventional NSAIDs
Neurological Deficits: Complete ptosis External ophthalmoplegia (III, IV, and VI cranial nerves affected) Arreactive mydriasis
Associated Symptoms: Binocular diplopia in all directions Ipsilateral V1 hypoesthesia Weight loss of 4 kg during the period
Physical/Neurological Examination: Ocular Motility (OS): Complete limitation of elevation, adduction, and abduction Trochlear nerve palsy (depression in adduction)
Sensory: Corneal hypoesthesia Abolished corneal reflex
General Examination: No lymphadenopathy or systemic signs
Complementary Exams: Orbital MRI with Contrast: Inflammatory lesion in the left cavernous sinus Homogeneous post-contrast enhancement Adjacent dural thickening
Cerebral MR Angiography: Exclusion of aneurysm or carotid-cavernous fistula
Laboratory: CRP: 48 mg/L Temporal artery biopsy: negative for arteritis
Report this case — e.g. suspected re-identification risk.