Case 428 · ICHD-3 6.8.4
6.8.4 Migraine-like aura attributed to cerebral amyloid angiopathy (CAA)
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Gender/Age: Male, 72 years
Background: Recent onset dementia (last 2 years), well-controlled hypertension
Medications: Ramipril 5mg/day, Donepezil 10mg/day
Family History: Father with Alzheimer's disease
History of Present Illness (HPI): Main symptom: Recurrent episodes of visual disturbances for 3 months
Characteristics of episodes:
Positive symptoms (zigzag photopsias)
Duration: 15-40 minutes
Frequency: 1-2 times/week
No associated headache
Occasionally followed by transient confusion (30-60 minutes)
Physical/Neurological Examination:
Mental status: MMSE 24/30 (deficits in recent memory and temporal orientation)
Neurological:
Brisk and symmetrical reflexes
Slightly unstable gait
No other focal deficits
Complementary Examinations:
Brain MRI:
Multiple cortical and subcortical microhemorrhages (predominantly occipital)
Marked hemosiderin deposits
Moderate leukoaraiosis
Amyloid PET: Positive pattern compatible with amyloid deposition
CSF: Total protein 55mg/dL, reduced beta-amyloid 42
Report this case — e.g. suspected re-identification risk.