Case 476 · ICHD-3 7.3.4
7.3.4 Headache attributed to lymphocytic hypophysitis
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Sex/Age: Male, 42 years
History: Type 1 diabetes mellitus (since age 15), no other comorbidities
Medication: NPH and regular insulin
History of Present Illness (HPI): Main symptom: Holocranial headache for 6 weeks
Pain characteristics:
Location: Diffuse, predominantly frontal
Character: Constant pressure
Intensity: 6-7/10
Course: Progressive, worsening in the morning
Associated symptoms:
Significant asthenia
Postural hypotension
Loss of libido
Occasional double vision
Physical/Neurological Examination: General: Skin hypopigmentation
Neurological:
Bilateral limitation of extraocular motility
Decreased deep tendon reflexes
Other findings:
Blood pressure: 100/60 mmHg
Heart rate: 62 bpm
Additional Tests: Magnetic Resonance Imaging of the Sella Turcica:
Symmetrical enlargement of the pituitary gland (15mm)
Adjacent meningeal enhancement
Absence of "stalk" signal
Laboratory:
8 AM serum cortisol: 2.1 μg/dL
TSH: 1.2 mIU/L with free T4: 0.6 ng/dL
Total testosterone: 120 ng/dL
Blood glucose: 180 mg/dL (fasting)
Report this case — e.g. suspected re-identification risk.