Case 482 · ICHD-3 7.3.5
7.3.5 Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL)
- Origin
- Synthetic
- Language
- English — also available in German
- Contributed by
- Imported case — HeadAI synthetic vignettes (de Andrade JBC, da Silva Costa TB, Vasconcelos JL, Lopes TLM, Balsells MD, Cristofolini VL, Querobin SO, Filho FMR. Validation of an AI-based platform for structured diagnosis of headache disorders using ICHD-3 criteria. BMC Neurology 25, 489 (2025). doi:10.1186/s12883-025-04473-1. Dataset: Andrade J. Head.AI Platform. Mendeley Data, V2 (2025). doi:10.17632/4fms6cw2s5.2)
Anamnesis
Identification: Sex/Age: Male, 25 years.
History: Previously healthy, with no history of migraine or recent infections.
History of Present Illness (HPI): Main symptom: Recurrent episodes of severe headache associated with transient neurological deficits over the past 3 days.
Headache characteristics:
Location: Unilateral (left hemicrania).
Character: Pulsatile.
Intensity: 8/10.
Duration: 1-2 hours per episode.
Associated symptoms: Photophobia, phonophobia, and nausea.
Transient neurological deficits:
Episode 1: Paresthesias in the right hemibody (20 minutes).
Episode 2: Dysarthria and weakness in the right arm (30 minutes).
Complete recovery after each episode.
Physical/Neurological Examination:
General: Conscious, oriented, afebrile.
Neurological:
No focal deficits at the time of examination.
Normal reflexes, no meningeal signs.
Complementary Exams:
Cerebrospinal Fluid (CSF):
Lymphocytic pleocytosis (80 cells/mm³).
Slightly elevated protein (60 mg/dL).
Normal glucose.
Negative cultures.
Cranial MRI and Angiography: Normal.
EEG: Temporal slow waves without epileptiform activity.
Report this case — e.g. suspected re-identification risk.